The Bioavailability Challenge
In the world of nutraceuticals, even the most powerful ingredients can only work if the body can absorb them. Unfortunately, many natural actives, like curcumin, resveratrol, CoQ10, or omega-3 oils, face a common problem: poor solubility and limited bioavailability. This means that even high doses may not translate into meaningful benefits.
Pharmako Biotechnologies, an Australian leader in delivery science, was founded on a simple yet ambitious goal: to make effective ingredients work better. By developing a range of complementary technologies, AquaCelle®, LipiSperse®, CPO®, and PlexoZome®, Pharmako has created a unified platform to enhance absorption, boost stability, and expand formulation options across liquids, powders, and capsules.
A Unified Story of Innovation
Rather than offering a one-size-fits-all solution, Pharmako’s technologies work together as a toolbox for formulators. Each platform addresses a specific challenge: solubilizing lipophilic actives, converting oils into powders, or stabilizing sensitive compounds within liposomes. Together, they form a coherent strategy for optimizing both performance and consumer experience.
Here’s how the pieces fit together:
AquaCelle®: Turning Oils into Absorbable Actives
AquaCelle® is a self-emulsifying drug delivery system (SEDDS) that transforms oily or lipophilic ingredients into fine micelles when they contact water. This allows ingredients like CoQ10 or omega-3 fatty acids to disperse efficiently within the gastrointestinal tract, leading to significantly higher absorption.
It’s ideal for:
- Liquid formulations and softgels
- Lipophilic actives (fat-soluble vitamins, oils, plant extracts)
- Brands seeking measurable improvements in bioavailability (often 3–6× increases in absorption)
AquaCelle® effectively “sets the stage” for the rest of Pharmako’s technologies—demonstrating how smart emulsification can make actives truly functional.
LipiSperse®: Cold Water Dispersion for Powders
While AquaCelle® shines in liquid systems, LipiSperse® was designed for powders. This patented cold-water dispersible technology coats lipophilic particles to prevent clumping and improve surface wettability. The result? Powders that disperse evenly in water or within the digestive tract—ideal for sports nutrition, instant beverages, or capsules that dissolve quickly.
It’s ideal for:
- Lipophilic powders like curcumin, resveratrol, or carotenoids
- Applications where water dispersibility and convenience matter
- Improving absorption while enhancing sensory appeal and product uniformity
LipiSperse® bridges the gap between solubility and consumer experience, offering formulators a practical route to high-performance functional powders.
CPO®: Compressible Powdered Oils for Solid Dosage Forms
Oils offer many health benefits but are notoriously tricky to handle in tablets or capsules. CPO® (Compressible Powdered Oils) solves this challenge by converting liquid oils into stable, free-flowing powders without sacrificing bioactivity.
It’s ideal for:
- Converting fish, algal, or botanical oils into dry forms
- Creating uniform blends for tablets or powder sachets
- Extending formulation options for previously “unusable” oils
CPO® complements AquaCelle® perfectly, turning the same high-performing oils that disperse well in liquids into compressible solids for broader market reach.
PlexoZome®: Advanced Liposomal Delivery
PlexoZome® represents Pharmako’s leap into liposomal encapsulation technology, a complex but powerful approach for delivering hydrophilic and lipophilic actives within a phospholipid bilayer. Liposomes protect sensitive ingredients (like polyphenols or peptides) from degradation and enhance uptake through cell membranes.
It’s ideal for:
- Sensitive, low-bioavailability actives (polyphenols, vitamins, peptides)
- Premium formulations requiring controlled or targeted delivery
- Brands seeking clinical-grade innovation and validation
PlexoZome®’s advanced characterization, using TEM, dynamic light scattering (DLS), and zeta potential testing, ensures reproducibility and stability, critical for maintaining efficacy from lab to shelf.
A Cohesive Portfolio with Flexible Choices
Pharmako’s technologies are not competitors; they are collaborators. Each one can stand alone or be layered strategically within a formulation strategy:
| Challenge | Pharmako Solution | Ideal Dosage Form | Example Actives |
| Poor oil solubility | AquaCelle® | Liquids, softgels | Omega-3s, CoQ10 |
| Poor water dispersibility | LipiSperse® | Powders, capsules | Curcumin, Resveratrol |
| Difficult-to-tablet oils | CPO® | Tablets, blends | Fish oil, Vitamin D |
| Sensitive active protection | PlexoZome® | Liquids, powders | Polyphenols, Peptides |
This modular approach allows formulators to choose the right technology based on ingredient chemistry, delivery format, and desired consumer experience.
Why Pharmako Leads the Field
Pharmako Biotechnologies stands out not just for its technologies but also for its philosophy. It combines scientific precision with market pragmatism, ensuring each solution is manufacturable, scalable, and validated by human studies.
- Proven clinical results (e.g., increased absorption for CoQ10 and Omega-3s)
- Cross-platform compatibility and IP protection
- Turnkey support for formulation, testing, and commercialization
By focusing on absorption, stability, and flexibility, Pharmako has built a reputation as the go-to partner for brands seeking to make clinically relevant, consumer-friendly nutraceuticals that deliver real-world results.
The Future: Smarter, Cleaner, Better Delivery
As consumer expectations evolve, demanding smaller doses, faster results, and cleaner labels, delivery technologies will continue to define the next generation of supplements and functional foods. Pharmako’s unified platform offers a roadmap for that future: scientifically proven, commercially viable, and endlessly adaptable.
In short, Pharmako doesn’t just make ingredients more bioavailable; it makes innovation itself more accessible.