The prevalence of high cholesterol necessitates effective and sustainable management strategies. While statins are the standard treatment, their side effects often impede long-term adherence. Introducing Citrus bergamia (Bergavit), a citrus fruit native to Southern Italy, as a promising natural alternative for managing cholesterol and lipid profiles. A new study has been published regarding a botanical extract from Citrus bergamia (Bergavit), demonstrating that it is an excellent choice for those looking to support their cholesterol levels. Let’s take a brief look at the study and its results.
Insights from the Clinical Trial
A recent randomized, double-blind, placebo-controlled clinical trial published in Foods (2024) highlights the effectiveness of a standardized flavonoid extract from Citrus bergamia (Bergavit). Conducted with 64 participants aged 40 to 70 who had untreated abnormal blood fats (such as cholesterol), the study evaluated the effects of 150 mg/day of bergamot flavonoids on cholesterol and lipid metabolism for four months.
Key Findings:
- Reduction in LDL-C and Total Cholesterol (TC):
- After four months, LDL-C levels dropped by 5%, moving participants from the “high” to “borderline high” categories.
- TC fell by 8%, beginning in the second month of supplementation.
- Increase in HDL-C (Good Cholesterol):
- HDL-C levels showed a 5% increase.
- Enhanced Antioxidant Activity:
- Oxidized LDL levels dropped, underscoring the extract’s cardioprotective potential.
- Safety and Tolerability:
- No adverse effects on liver, kidney, or glycemic markers were observed, demonstrating the product’s excellent safety profile.
How it Works
Bergamot flavonoids operate through multifaceted pathways:
- Lipid Regulation: Activation of Sirtuin-1 and AMPK-α pathways enhances fatty acid oxidation and reduces very-low-density lipoprotein (VLDL) synthesis.
- Cholesterol Clearance: Enhanced LDL receptor activity aids in the clearance of circulating LDL particles.
- Antioxidant Effects: Reduction in oxidative stress via decreased ox-LDL levels.
Why Choose Bergavit?
The appeal of Bergavit stems from its natural composition, few side effects, and substantial lipid-lowering properties. It serves as a viable alternative for individuals seeking a natural approach to managing their cholesterol.